| CAS Number: | 41575-94-4 |
| MDL Number: | MFCD00070464 |
| Molecular Formula: | C6H12N2O4Pt |
| Molecular Weight: | 371.26 |
| Chemical Formula: | C6H12N2O4Pt |
| Color and Form: | white xtl. |
| Note: |
| SECTION 1: Product Identification | |
|---|---|
| Chemical Name: | 1,1-Cyclobutanedicarboxylatodiammineplatinum (II), 99% (Carboplatin) |
| Product Number: | 78-0255 |
| CAS Registry Number: | 41575-94-4 |
| Formula: | C6H12N2O4Pt |
| EINECS Number: | 255-446-0 |
| Chemical Family: | metal-ammine complexes |
| Synonym: | Carboplatin, Diammine(1,1-cyclobutanedicarboxylato)platinum(II) |
| SECTION 2: Composition and Information on Ingredients | ||||
|---|---|---|---|---|
| Ingredient | CAS Number | Percent | ACGIH (TWA) | OSHA (PEL) |
| Title Compound | 41575-94-4 | 100 | 0.002mg/m3 | 0.002mg/m3 |
| SECTION 3: Hazards Identification | |
|---|---|
| Emergency Overview: | Harmful if swallowed. Irritating to skin, eyes and respiratory tract. May cause harm to the unborn child and heritable genetic damage. May cause sensitization by inhalation and skin contact. |
| Primary Routes of Exposure: | Ingestion, skin, inhalation of dust |
| Eye Contact: | Causes slight to mild irritation of the eyes. |
| Skin Contact: | Causes slight to mild irritation of the skin. May cause sensitization by skin contact. |
| Inhalation: | Irritating to the nose, mucous membranes and respiratory tract. May cause sensitization by inhalation. |
| Ingestion: | Harmful if swallowed. Ingestion may lead to dizziness, abdominal cramps, and vomiting. |
| Acute Health Effects: | Irritating to the skin, eyes, and respiratory tract. May cause sensitization by inhalation and skin contact. May cause harm to the unborn child. |
| Chronic Health Effects: | Soluble chloroplatinate salts may cause an allergic reaction known as platinosis. May cause heritable genetic damage. Mutagen and reproductive effector by RTECS criteria. |
| NTP: | No |
| IARC: | No |
| OSHA: | No |
| SECTION 4: First Aid Measures | |
|---|---|
| Eye Exposure: | Immediately flush the eyes with copious amounts of water for at least 10-15 minutes. A victim may need assistance in keeping their eye lids open. Get immediate medical attention. |
| Skin Exposure: | Wash the affected area with water. Remove contaminated clothes if necessary. Seek medical assistance if irritation persists. |
| Inhalation: | Remove the victim to fresh air. Closely monitor the victim for signs of respiratory problems, such as difficulty in breathing, coughing, wheezing, or pain. In such cases seek immediate medical assistance. |
| Ingestion: | Seek medical attention immediately. Keep the victim calm. Give the victim water (only if conscious). Induce vomiting only if directed by medical personnel. |
| SECTION 5: Fire Fighting Measures | |
|---|---|
| Flash Point: | not applicable |
| Autoignition Temperature: | none |
| Explosion Limits: | none |
| Extinguishing Medium: | none required |
| Special Fire Fighting Procedures: | If involved in a fire, fire fighters should be equipped with a NIOSH approved positive pressure self-contained breathing apparatus and full protective clothing. |
| Hazardous Combustion and Decomposion Products: | none |
| Unusual Fire or Explosion Hazards: | No unusual fire or explosion hazards. |
| SECTION 6: Accidental Release Measures | |
|---|---|
| Spill and Leak Procedures: | To avoid raising dust, small spills may be mixed with diatomaceous earth, sand, vermiculite or other suitable inert material and swept up. |
| SECTION 7: Handling and Storage | |
|---|---|
| Handling and Storage: | Store solid in a tightly sealed container. |
| SECTION 8: Exposure Controls and Personal Protection | |
|---|---|
| Eye Protection: | Always wear approved safety glasses when handling a chemical substance in the laboratory. |
| Skin Protection: | Wear appropriate chemical resistant gloves and protective clothing. |
| Ventilation: | If possible, handle the material in an efficient fume hood. |
| Respirator: | A respirator should be worn. The use of respirators requires a Respirator Protection Program to be in compliance with 29 CFR 1910.134. |
| Additional Protection: | No additional protection required. |
| SECTION 9: Physical and Chemical Properties | |
|---|---|
| Color and Form: | white xtl. |
| Molecular Weight: | 371.26 |
| Melting Point: | no data |
| Boiling Point: | no data |
| Vapor Pressure: | not applicable |
| Specific Gravity: | no data |
| Odor: | none |
| Solubility in Water: | Slightly soluble |
| SECTION 10: Stability and Reactivity | |
|---|---|
| Stability: | air and moisture stable |
| Hazardous Polymerization: | no hazardous polymerization |
| Conditions to Avoid: | none |
| Incompatibility: | oxidizing agents |
| Decomposition Products: | Carbon dioxide, carbon monoxide, organic vapors, and platinum oxide. |
| SECTION 11: Toxicological Information | |
|---|---|
| RTECS Data: | Oral (rat); LD50: 343 mg/kg. Subcutaneous (rat); LD50: 72 mg/kg. Intravenous (rat); LD50: 60900 ug/kg. Intraperitoneal (mouse); LD50: 118 mg/kg. Intravenous (mouse); LD50: 89360 ug/kg. Unreported (mouse); LD50: 180 mg/kg. Intravenous (dog); LD50: >31200 ug/kg. Unreported (mammal-species unspecified); LD50: 158 mg/kg. Intravenous (rat); TDLo: 70 mg/kg/2W-I. Intraperitoneal (mouse); TDLo: 32 mg/kg/5D-I. Intravenous (dog); TDLo: 140 mg/kg/26W-I. Intravenous (dog); TDLo: 60 mg/kg/5D-I. Reproductive: Intravenous (rat); TDLo: 24 mg/kg. Intravenous (rat); TDLo: 24 mg/kg. Human Lymphocyte; Micronucleus test: 500 nmol/L. Human Cells. |
| Carcinogenic Effects: | no data |
| Mutagenic Effects: | Mutagen |
| Tetratogenic Effects: | Reproductive effector |
| SECTION 12: Ecological Information | |
|---|---|
| Ecological Information: | No information available |
| SECTION 13: Disposal Considerations | |
|---|---|
| Disposal: | Dispose of according to local, state and federal regulations. |
| SECTION 14: Transportation | |
|---|---|
| Shipping Name (CFR): | Non-hazardous |
| Hazard Class (CFR): | NA |
| Additional Hazard Class (CFR): | NA |
| Packaging Group (CFR): | NA |
| UN ID Number (CFR): | NA |
| Shipping Name (IATA): | Non-hazardous |
| Hazard Class (IATA): | NA |
| Additional Hazard Class (IATA): | NA |
| Packaging Group (IATA): | NA |
| UN ID Number (IATA): | NA |
| SECTION 15: Regulatory Information | |
|---|---|
| TSCA: | Not listed in the TSCA inventory. |
| SARA (Title 313): | Title compound not listed. |
| Second Ingredient: | none |
| Third Ingredient: | none |
| SECTION 16: Other Information | |
|---|---|
| Disclaimer: | The information herein is believed to be accurate and reliable as of the date compiled. However, Strem Chemicals, Inc. makes no representation, warranty, or guarantee of any kind with respect to the information contained in this document or any use of the product based on this information. |
| Preparation Date: | 2/27/2002 |
| Revision Date: | 8/15/2011 |