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High Purity Chiral Sulfinamide Phosphines from Daicel

Ligands and organocatalysts with structural diversity and good practical stability

The Strem Catalog by Ascensus Specialties offers an expanded range of high quality chiral ligands and phosphoric acids in collaboration with Daicel. Using proprietary knowledge for chiral separation and enantioselective resolution of racemates, Daicel provides chiral products with ≥98% chemical purity values and up to ≥99% enantiomeric excesses values.

In previous blogs, we have been reporting about Chiral Phosphoric Acid Catalysts, Thiourea Based Bifunctional Chiral Catalysts, Proline Based Organocatalysts, and Bifunctional Chiral Squaramide Organocatalysts. These high quality chiral reagents represent a very important class of asymmetric organocatalysts and ligands that are able to efficiently catalyze various organic reactions under mild and environmentally friendly conditions [1-6].

Image1

Fig. 1. General structures of chiral sulfinamide phosphine ligands

The Strem Catalog offers a wide range of chiral SulfinAmiDe Phosphine (SAD-Phos) ligands and organocatalysts. These products outshine in structural diversity and strong practical stability. Upon practical applications, the sulfinamide phosphine ligands have shown good catalytic performance in a series of asymmetric organocatalytic reactions [7], copper catalyzed intermolecular cycloaddition [8], and Pd-catalyzed enantioselective coupling reactions [9-12].

References:

  1.    Chem. Rev., 2014, 114, 9047.
  2.    Chem. Rev., 2015, 115, 9277.
  3.    Adv. Synth. Catal., 2009, 351, 33.
  4.    Chem. Soc. Rev., 2010, 39, 1600.
  5.    Angew. Chem. Int. Ed. 2016, 55, 14663.
  6.    Chem. Rec. 2017, 17, 994.
  7.    Angew. Chem. Int. Ed. 2015, 54, 14853.
  8.    Angew. Chem. Int. Ed. 2016, 55, 6324.
  9.    Angew. Chem. Int. Ed. 2018, 57, 10373.
  10.    J. Am. Chem. Soc. 2019, 141, 19246.
  11.    J. Am. Chem. Soc. 2020, 142, 9763.
  12.    Angew. Chem. Int. Ed. 2020, 59, 22957.

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Related Resources & Product Lines

SadPhos Ligands

High Purity Chiral Reagents

Chiral Phosphoric Acids

 

 

 

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