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Cucurbiturils are macrocyclic molecules acting as hosts for an array of neutral and cationic species

Strem Chemicals proudly announces the Cucurbituril Kit (96-7054) is currently available in our catalog.  Cucurbit[n]uril (CB[n], n = 5-10) is a family of macrocyclic compounds comprising n glycoluril units, self-assembled from an acid-catalyzed condensation reaction of glycoluril and formaldehyde.^16-19 The pumpkin-shaped CB molecules have a hydrophobic cavity and two identical carbonyl-laced portals. 

While the hydrophobic interior provides a potential inclusion site for nonpolar molecules, the polar urido carbonyl groups at the portals allow CB[n] to bind ions and molecules through charge-dipole and hydrogen bonding interactions.^{1,17,5, 20} The unique structure and recognition

properties make CB[n] attractive not only as a synthetic receptor, but also as a building block for the construction of supramolecular architectures.^16,21,22 Furthermore, a direct functionalization method²³ of CB[n] allowed the synthesis of a wide variety of tailor-made CB derivatives, which can be used to study manyapplications. Ion channels, vesicles, polymers, nanomaterials, ion selective electrodes incorporating CB[n], and CB-immobilized solid surfaces and silica gel have been reported. Numerous other applications are being explored.¹⁸ Cucurbiturils are new and important players in field of supramolecular chemistry. ^{9, 24, 25}

Applications include: 

1. Chambers for chemical reactions^{1, 2}
2. Sensors for organic amines³
3. Utility in the reduction of pollutions⁴
4.  Laser dye applications⁵
5. Molecular machines⁶
6. Gene and drug delivery vehicles^7,8,9,11
7. Useful for bio-related applications, such as ion channel¹², enzyme assay¹³, protein chips,¹⁴ and selective protein isolation¹⁵

Product mentioned in this blog:

96-7054: Cucurbituril Kit

Visit the link below to read more about this kit on our website:

Additional details about Cucurbituril Kit

References:

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12. Y. J. Jeon et al., J. Am. Chem. Soc., 2004, 126, 15944.

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16. K. Kim, Chem. Soc. Rev., 2002, 31, 96.

17. J. Lagona et al., Angew. Chem. Int. Ed., 2005, 44, 4844.

18. K. Kim et al., Chem. Soc. Rev., 2007, 36, 267.

19. (a) J. Kim et al., J. Am. Chem. Soc., 2000, 122, 540; (b) A. Day et al., J. Org. Chem., 2001, 66, 8094.

20. (a) W. S. Jeon et al., J. Am. Chem. Soc., 2005, 127, 12984; (b) S. Liu et al., J. Am. Chem. Soc., 2005, 127, 15959; (c) Y. Kim et al., Chem. Eur. J., 2009,15, 6143.

21. Y. H. Ko et al., Chem. Commun., 2007, 1305.

22 (a) D. Tuncel and J. H. G. Steinke, Chem. Commun., 1999, 1509; (b) D. Sobransingh and A. E. Kaifer, Langmuir, 2006,22, 10540; (c) E. A.

23. S. Y. Jon et al., J. Am. Chem. Soc., 2003, 125, 10186.

24. (a) Coordin. Chem. Rev., 2015, 287, 89-113, (b) Accounts Chem. Res., 2014, 47(7), 2052-62.

25. (a) Chirality, 2014, 26(11), 712-723.(b) J. Am. Chem. Soc., 2014, 136(48), 16744-47, (c) Angew Chem. Int. Edit.,2014, 53(40), 10 582-84.

26. Appel et al., J. Am. Chem. Soc., 2010,132, 14251.