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Enhancing the Chiral Phosphoric Acid Catalysts – New Important Arrivals!

New BINOL-, SPINOL- and TADDOL based chiral phosphoric acids are available

In our previous blog, we have provided detailed discussions on mechanistic aspects of chiral phosphoric acid (CPA)-catalyzed asymmetric reactions that were initiated by BINOL structured catalysts.

Now, we are pleased to introduce 60 new CPAs that are designed on the BINOL, SPINOL- and TADDOL skeleton scaffold (Fig. 1). Compared to BINOL CPAs,SPINOL- and TADDOL classes of catalysts are less explored, and therefore open new horizons for researchers. 


Figure 1. Examples of chiral phosphoric acid promoted asymmetric synthesis

BINOL-, SPINOL- and TADDOL- based chiral phosphoric acid catalysts represent a very important class of asymmetric organocatalysts that are able to catalyze a wide range of organic reactions under mild and environmentally friendly conditions (a few examples are shown Fig. 1) [1-8]. Transformations catalyzed by CPAs have an advantage with high yields and excellent enantioselectivities. Detailed individual product information is reviewed in the corresponding technical note here.

Click here to access our full list Chiral Phosphoric Acids.



  1.        Acc. Chem. Res., 2011, 44, 1156.
  2.        Chem. Rev., 2014, 114, 9047.
  3.        Chem. Rev., 2015, 115, 9388.
  4.        Chem. Rev., 2016, 116, 4006.
  5.        Chem. Rev., 2017, 117, 9433.
  6.        Chem. Soc. Rev., 2018, 47, 1142.
  7.        Acc. Chem. Res., 2018, 51, 534.
  8.        Chem. Soc. Rev., 2020, 49, 286.


Featured Products & Related Materials:

Chiral Phosphoric Acids Product Listing

Chiral Phosphoric Acids Literature Sheet

Chiral Phosphoric Acids Booklet


Metal Catalysts Booklet



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