Sodium borohydride has found application as a reducing agent in synthetic procedures of demanding life science applications such as:
NaBH4 is increasingly becoming important for many organic transformations because of its availability, low cost, and easy handling. It easily fits the demanding reaction conditions both in basic reactions such as the reduction of ketones and aldehydes to alcohols, as well as with organic transformations of highly complex functionalized molecules.
VENPURE™ sodium borohydride is a critical tool for synthesis chemists who are performing high yield reductions at both lab and production scale. Key benefits valued by synthesis chemists are:
NaBH4 has found its way into a number of applications such as reductive amination, conversion of alcohols into imines1 Harries ozonolysis, reductive alkylation of primary and secondary amines and N,N-dimethylation of amino acids, reductive amination of aldehydes and ketones2, conversion of azides to amines and many others. It efficiently reduces acyl chlorides, anhydrides, α-hydroxylactones, thioesters, and imines at room temperature or below.
VENPURE™ sodium borohydride is available in the Strem Catalog in several modifications:
11-1117 VENPURE™ AF CAPLETS (sodium borohydride), min. 99%
11-1119 VENPURE™ SF GRANULE (sodium borohydride), min. 98.5%
93-1118 VENPURE™ SF POWDER (sodium borohydride), min. 98.5%
11-1120 VENPURE™ AF GRANULE (sodium borohydride), min. 99%
11-1121 VENPURE™ SOLUTION (sodium borohydride 12%; sodium hydroxide 40%)
References
1. Org. Lett., 2001, 3, 1637.
2. Tetrahedron, 2005, 61, 5725.
Featured Products
11-1117 VENPURE™ AF CAPLETS (sodium borohydride), min. 99%
11-1119 VENPURE™ SF GRANULE (sodium borohydride), min. 98.5%
93-1118 VENPURE™ SF POWDER (sodium borohydride), min. 98.5%
11-1120 VENPURE™ AF GRANULE (sodium borohydride), min. 99%
11-1121 VENPURE™ SOLUTION (sodium borohydride 12%; sodium hydroxide 40%)
11-1122 VENPURE™ 930 Solution (sodium borohydride 9%; sodium hydroxide 30%) [Coming Soon!]
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