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An efficient and environmentally friendly catalyst for organic transformations

ZnTAC24® is a tetranuclear zinc cluster that is a highly efficient catalyst for a wide range of organic transformations.¹ This catalyst, sold in collaboration with Takasago is available in our product catalog (30-4050).

This catalyst was first introduced by the Mashima group at Osaka University. After the first introduction, ZnTAC24® has been used by researchers worldwide as an acidic catalyst. For instance, the promising influence of this catalyst has been reported: a) in the direct formation of oxazolines from esters, carboxylic acids, lactones,² and nitriles, b) in the transesterification⁷ of various methyl esters³ including α-amino esters and β-keto esters, c) in the acetylation of alcohols⁴ in EtOAc, and d) in the deacylation of esters in MeOH.⁶ One of the unique properties of ZnTAC24® is the acylation of hydroxyl (OH) groups selectively in the presence of inherently much more nucleophilic amino groups.⁴ Cycloisomerization catalyzed reactions have also been reported.⁵

References

1.      For a review see: Chem. Pharm. Bull. 2016, 64, 523.
2.      Chem. Comm. 2006, 2711.
3.      J.Org. Chem. 2008, 73, 5147.
4.      J. Am. Chem. Soc. 2008, 130, 2944.
5.      J.Org. Chem. 2008, 73, 5881.
6.      RSC Adv. 2016, 6, 58749.
7.      Catal. Sci. Technol. 2011, 1, 230.

30-4050 Oxo[hexa(trifluoroacetato)]tetrazinc trifluoroacetic acid adduct ZnTAC24™ (1276028-18-2)

Catalysis